bis -(p-hydroxyphenyl)-pyridyl-2-methane (BHPM)-the active metabolite of the laxatives bisacodyl and sodium picosulfate-enhances contractility and secretion in human intestine in vitro

Author:

Krueger D.1,Demir I. E.2,Ceyhan G. O.2,Zeller F.3,Schemann M.1ORCID

Affiliation:

1. Human Biology; Technische Universität München; Freising Germany

2. Department of Surgery; Klinikum Rechts der Isar Technische Universität München; Munich Germany

3. Surgery; Clinic Freising; Freising Germany

Funder

Boehringer Ingelheim

Publisher

Wiley

Subject

Gastroenterology,Endocrine and Autonomic Systems,Physiology

Reference25 articles.

1. Comparison of efficacy of pharmacological treatments for chronic idiopathic constipation: a systematic review and network meta-analysis;Nelson;Gut,2017

2. Oral bisacodyl is effective and well-tolerated in patients with chronic constipation;Kamm;Clin Gastroenterol Hepatol,2011

3. Bis-(p-hydroxyphenyl)-pyridyl-2-methane: the common laxative principle of bisacodyl and sodium picosulfate;Jauch;Arzneimittelforschung,1975

4. Pharmakokinetik und laxierende Wirkung von Bisacodyl nach Gabe verschiedener Zubereitungsformen;Roth;Arzneimittelforschung,1988

5. Effects of sennosides A + B and bisacodyl on rat large intestine;Leng-Peschlow;Pharmacology,1989

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