Filaggrin loss-of-function mutations are not associated with atopic dermatitis that develops in late childhood or adulthood
Author:
Affiliation:
1. Department of Dermatovenereology; University Medical Centre Ljubljana; Ljubljana Slovenia
2. Dermatology Centre Arsderma; Ljubljana Slovenia
3. University Clinic of Respiratory and Allergic Diseases; Golnik Slovenia
Publisher
Wiley
Subject
Dermatology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bjd.13477/fullpdf
Reference37 articles.
1. Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens;Scharschmidt;J Allergy Clin Immunol,2009
2. Filaggrin mutations associated with skin and allergic diseases;Irvine;N Engl J Med,2011
3. Unique and recurrent mutations in the filaggrin gene in Singaporean Chinese patients with ichthyosis vulgaris;Chen;J Invest Dermatol,2008
4. R501X and 2282del4 filaggrin mutations do not confer susceptibility to psoriasis and atopic dermatitis in Italian patients;Giardina;Dermatology,2008
5. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis;Palmer;Nat Genet,2006
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