Affiliation:
1. Department of Dermatology Grand Hôpital de Charleroi Charleroi Belgium
2. Department of Dermatology Cliniques Universitaires Saint‐Luc Brussels Belgium
3. Department of Anatomopathology Cliniques Universitaires Saint‐Luc Brussels Belgium
Abstract
AbstractWe report a case of congenital multisystem Langerhans cell histiocytosis with cutaneous and hematopoietic involvement. After the failure of first‐line (vinblastine and prednisolone) and second‐line (vincristine and cytarabine) therapies, treatment with cobimetinib, a mitogen‐activated protein kinase (MEK) inhibitor, led to the remission of disease and a sustained response after 11 months of ongoing treatment. Protein kinase inhibitors targeting BRAF or MEK could represent a promising future therapeutic option, also in children with LCH.