ACOPP’ chemotherapy for older and less fit patients with Hodgkin lymphoma—A multicentre, retrospective study

Author:

Wilson Matthew R.1ORCID,Haynes Euan2,Parsons Katrina1,Hopkins David1,Robertson Elizabeth3,Ferguson Graeme1,Quinn Daire1,Murray Jim3,Osborne Wendy2,Leach Mike1,McKay Pam1ORCID

Affiliation:

1. Department of Haematology Beatson West of Scotland Cancer Centre Glasgow UK

2. Department of Haematology Newcastle Upon Tyne NHS Foundation Trust Newcastle Upon Tyne UK

3. Department of Haematology Royal United Hospital Bath NHS Trust Bath UK

Abstract

SummaryManagement of classical Hodgkin lymphoma in older patients is challenging due to poor tolerance of the chemotherapy regimens used in younger patients. We modified the BEACOPP regimen (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine and prednisolone), whereby bleomycin and etoposide were removed and cyclophosphamide dose was reduced, for older patients with co‐morbidities. Here we present data from the first 41 patients treated with ‘ACOPP’ across 3 centres, demonstrating that it can be delivered, with a favourable toxicity profile (TRM 2%) and promising efficacy (2‐year PFS and OS, 73% (95% CI: 52–94) and 93% (95% CI: 80–100) respectively).

Publisher

Wiley

Subject

Hematology

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