Preclinical evaluation of the abuse potential of Pitolisant, a histamine H3receptor inverse agonist/antagonist compared with Modafinil

Author:

Uguen M1,Perrin D1,Belliard S1,Ligneau X1,Beardsley PM2,Lecomte JM1,Schwartz JC1

Affiliation:

1. Bioprojet-Biotech; Saint Grégoire Cedex; France

2. Department of Pharmacology & Toxicology; Virginia Commonwealth University; Richmond; VA; USA

Publisher

Wiley

Subject

Pharmacology

Reference60 articles.

1. Dopamine transporter-related effects of modafinil in rhesus monkeys;Andersen;Psychopharmacology (Berlin),2010

2. Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist;Barbier;Br J Pharmacol,2004

3. The self-administration of MK-801 can depend upon drug-reinforcement history, and its discriminative stimulus properties are phencyclidine-like in rhesus monkeys;Beardsley;J Pharmacol Exp Ther,1990

4. Modafinil reinstates a cocaine conditioned place preference following extinction in rats;Bernardi;Behav Brain Res,2009

5. The H3 antagonist thioperamide reveals conditioned preference for a context associated with an inactive small dose of cocaine in C57BL/6J mice;Brabant;Behav Brain Res,2005

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