The changes in mycolic acid structures caused byhadCmutation have a dramatic effect on the virulence ofMycobacterium tuberculosis

Author:

Slama Nawel12,Jamet Stevie12,Frigui Wafa3,Pawlik Alexandre3,Bottai Daria3,Laval Françoise12,Constant Patricia12,Lemassu Anne12,Cam Kaymeuang12,Daffé Mamadou12,Brosch Roland3,Eynard Nathalie1,Quémard Annaïk12

Affiliation:

1. Département Tuberculose & Biologie des Infections; Institut de Pharmacologie et de Biologie Structurale - UMR5089; Centre National de la Recherche Scientifique; Toulouse France

2. Institut de Pharmacologie et de Biologie Structurale; Université de Toulouse; Université Paul Sabatier; Toulouse France

3. Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics; Paris France

Funder

CNRS, Université de Toulouse-UPS, Ibisa

European Union

EU-EFPIA Innovative Medicines Initiative

Agence Nationale de la Recherche

Fondation pour la Recherche Médicale

Publisher

Wiley

Subject

Molecular Biology,Microbiology

Reference57 articles.

1. A modified Ziehl-Neelsen stain for Mycobacteria;Allen;Med Lab Sci,1992

2. The fate of virulent and attenuated Mycobacteria in guinea pigs infected by the respiratory route;Alsaadi;Am Rev Respir Dis,1973

3. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs;Altschul;Nucleic Acids Res,1997

4. Mutations in the essential FAS II beta-hydroxyacyl ACP dehydratase complex confer resistance to thiacetazone in Mycobacterium tuberculosis and Mycobacterium kansasii;Belardinelli;Mol Microbiol,2012

5. Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice;Bhatt;Proc Natl Acad Sci USA,2007

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