Predicted expression of genes involved in the thiopurine metabolic pathway and azathioprine discontinuation due to myelotoxicity-Reference-Cited by-同舟云学术

Predicted expression of genes involved in the thiopurine metabolic pathway and azathioprine discontinuation due to myelotoxicity

Published:2022-02-20 Issue:4 Volume:15 Page:859-865
ISSN:1752-8054
Container-title:Clinical and Translational Science
language:en
Short-container-title:Clinical Translational Sci

Author:

Daniel Laura L.¹^ORCID,Dickson Alyson L.¹,Zanussi Jacy T.¹,Miller‐Fleming Tyne W.¹^ORCID,Straub Peter S.¹,Wei Wei‐Qi²,Plummer W. Dale³,Dupont William D.³,Liu Ge¹,Anandi Prathima¹,Reese Tyler S.¹,Birdwell Kelly A.¹,Kawai Vivian K.¹,Hung Adriana M.¹⁴,Cox Nancy J.¹,Feng QiPing¹,Stein C. Michael¹,Chung Cecilia P.¹⁴^ORCID

Affiliation:

1. Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA

2. Department of Biomedical Informatics Vanderbilt University Medical Center Nashville Tennessee USA

3. Department of Biostatistics Vanderbilt University Medical Center Nashville Tennessee USA

4. Tennessee Valley Healthcare System Nashville Virginia USA

Funder

National Center for Advancing Translational Sciences

National Institute of General Medical Sciences

National Institutes of Health

Georgia Clinical and Translational Science Alliance

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cts.13243

Reference30 articles.

1. Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience.

2. Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism

3. PharmGKB.Thiopurine Pathway Pharmacokinetics/Pharmacodynamics.https://www.pharmgkb.org/pathway/PA2040/components. Accessed September 8 2021.

4. Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT 15 Genotypes: 2018 Update

5. A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

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