Influence of vasopressin receptor antagonists on triple‐whammy acute kidney injury: A VigiBase analysis

Abstract

Although diuretics play an important role in triple‐whammy acute kidney injury (AKI), it is unclear whether the type of diuretic influences the risk of triple‐whammy AKI. The aim of this study was to evaluate whether vasopressin receptor antagonists affect triple‐whammy AKI. This cross‐sectional study used disproportionality analysis of VigiBase data to assess the risk of AKI with various diuretics. Although multiple logistic regression analysis showed that aldosterone antagonists (odds ratio [OR] 2.19, 95% CI 2.01–2.37), loop diuretics (OR 4.40, 95% CI 4.07–4.76) and thiazide diuretics (OR 1.98, 95% CI 1.83–2.15) increased the risk of AKI in patients who received non‐steroidal anti‐inflammatory drugs (NSAIDs) and renin‐angiotensin system inhibitors (RASi), vasopressin receptor antagonists did not increase the risk of AKI in those patients. Vasopressin receptor antagonists might not influence the development of triple‐whammy AKI.