Calcium modulation of doxorubicin cytotoxicity in yeast and human cells

Author:

Nguyen Thi Thuy Trang12,Lim Ying Jun12,Fan Melanie Hui Min12,Jackson Rebecca A.1,Lim Kim Kiat12,Ang Wee Han3,Ban Kenneth Hon Kim12,Chen Ee Sin1245

Affiliation:

1. Department of Biochemistry; Yong Loo Lin School of Medicine; National University of Singapore; Singapore

2. National University Health System; Singapore

3. Department of Chemistry; Faculty of Science; National University of Singapore; Singapore

4. NUS Graduate School of Science & Engineering; National University of Singapore; Singapore

5. NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI); Life Sciences Institute; National University of Singapore; Singapore

Funder

Singapore Ministry of Education Tier II

Publisher

Wiley

Subject

Cell Biology,Genetics

Reference67 articles.

1. The VPH2 gene encodes a 25 kDa protein required for activity of the yeast vacuolar H(+)-ATPase;Bachhawat;Yeast,1993

2. Calcium signalling: dynamics, homeostasis and remodelling;Berridge;Nat. Rev. Mol. Cell Biol.,2003

3. Role of DNA breakage in cytotoxicity of doxorubicin, 9-deoxydoxorubicin, and 4-demethyl-6-deoxydoxorubicin in murine leukemia P388 cells;Capranico;Cancer Res.,1989

4. Schizosaccharomyces pombe ehs1p is involved in maintaining cell wall integrity and in calcium uptake;Carnero;Mol. Gen. Genet.,2000

5. Doxorubicin: the good, the bad and the ugly effect;Carvalho;Curr. Med. Chem.,2009

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