Evaluation of the Potency of Two Novel Bispyridinium Oximes (K456, K458) in Comparison with Oxime K203 and Trimedoxime to Counteract Tabun-Induced Neurotoxicity in Rats-Reference-Cited by-同舟云学术

Evaluation of the Potency of Two Novel Bispyridinium Oximes (K456, K458) in Comparison with Oxime K203 and Trimedoxime to Counteract Tabun-Induced Neurotoxicity in Rats

Published:2013-05-29 Issue:3 Volume:113 Page:201-208
ISSN:1742-7835
Container-title:Basic & Clinical Pharmacology & Toxicology
language:en
Short-container-title:Basic Clin Pharmacol Toxicol

Author:

Kassa Jiri¹,Misik Jan¹,Karasova Jana Z.²

Affiliation:

1. Department of Toxicology; Faculty of Military Health Sciences; Hradec Kralove; Czech Republic

2. Department of Public Health; Faculty of Military Health Sciences; Hradec Kralove; Czech Republic

Publisher

Wiley

Subject

Pharmacology,Toxicology,General Medicine

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcpt.12083/fullpdf

Reference37 articles.

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3. Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds;Jokanovic;Curr Med Chem,2009

4. Two possibilities how to increase the efficacy of antidotal treatment of nerve agent poisonings;Kassa;Mini-Rev Med Chem,2012

5. Tabun - reappearance 50 years later (in Czech);Cabal;Chem Listy,1999

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1. Oxime K203: a drug candidate for the treatment of tabun intoxication;Archives of Toxicology;2018-12-18

2. A Comparison of the Reactivating and Therapeutic Efficacy of Two Newly Developed Oximes (K727 and K733) with Oxime K203 and Trimedoxime in Tabun-Poisoned Rats and Mice;Basic & Clinical Pharmacology & Toxicology;2014-10-24

3. In VivoEvaluation of Cholinesterase Activity, Oxidative Stress Markers, Cyto- and Genotoxicity of K048 Oxime - a Promising Antidote against Organophosphate Poisoning;Basic & Clinical Pharmacology & Toxicology;2013-11-11