Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors

Author:

Molgó Jordi12,Marchot Pascale3,Aráoz Rómulo12,Benoit Evelyne12,Iorga Bogdan I.4,Zakarian Armen5,Taylor Palmer6,Bourne Yves3,Servent Denis1

Affiliation:

1. Commissariat à l'Energie Atomique et aux énergies alternatives (CEA); Institut de Biologie et Technologies de Saclay (IBITECS); Université Paris-Saclay; Service d'Ingénierie Moléculaire des Protéines; Gif-sur-Yvette France

2. Institut des Neurosciences Paris-Saclay; UMR 9197; Centre National de la Recherche Scientifique (CNRS)/Université Paris-Sud; Gif-sur-Yvette Cedex France

3. Aix-Marseille Université / Centre National de la Recherche Scientifique; Architecture et Fonction des Macromolécules Biologiques laboratory; Marseille France

4. Centre National de la Recherche Scientifique (CNRS); Institut de Chimie des Substances Naturelles; UPR 2301; Labex LERMIT; Gif-sur-Yvette France

5. Department of Chemistry and Biochemistry; University of California Santa Barbara; Santa Barbara California USA

6. Department of Pharmacology; Skaggs School of Pharmacy and Pharmaceutical Sciences; University of California, San Diego; La Jolla California USA

Funder

Agence Nationale de la Recherche

French Infrastructure for Integrated Structural Biology (FRISBI)

CNRS-DRI PICS

National Institutes of Health

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Reference93 articles.

1. Algal toxins and producers in the marine waters of Qatar, Arabian Gulf;Al Muftah;Toxicon,2016

2. Mammalian nicotinic acetylcholine receptors: from structure to function;Albuquerque;Physiol. Rev.,2009

3. Toxic strains of the Alexandrium ostenfeldii complex in southern South America (Beagle Channel, Argentina);Almandoz;Harmful Algae,2014

4. The globally distributed genus Alexandrium: multifaceted roles in marine ecosystems and impacts on human health;Anderson;Harmful Algae,2012

5. The emergent marine dinoflagellate toxins spirolides and gymnodimines target nicotinic acetylcholine receptors;Aráoz;Biol. Res.,2009

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