Early withdrawal of calcineurin inhibitor from a sirolimus-based immunosuppression stabilizes fibrosis and the transforming growth factor-β signalling pathway in kidney transplant

Author:

Rivelli Regiane F12,Gonçalves Renato T12,Leite Maurilo12,Santos Marcos André R12,Delgado Alvimar G12,Cardoso Lucio R12,Takiya Christina M23

Affiliation:

1. Faculty of Medicine; Federal University of Rio de Janeiro; CEP 21941-902 Rio de Janeiro Brazil

2. Nephrology Service; University Hospital Clementino Fraga Filho; Federal University of Rio de Janeiro; CEP 21941-902 Rio de Janeiro Brazil

3. Institute of Biophysics Carlos Chagas Filho; Federal University of Rio de Janeiro; CEP 21941-902 Rio de Janeiro Brazil

Publisher

Wiley

Subject

Nephrology,General Medicine

Reference35 articles.

1. The natural history of chronic allograft nephropathy;Nankivell;N. Engl. J. Med.,2003

2. Expression of TGF-beta and fibrogenic genes in transplant recipients with tacrolimus and cyclosporine nephrotoxicity;Goldfarb;J. Urol.,2003

3. Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506;Akool el;J. Immunol.,2008

4. Oligomeric structure of type I and type II transforming growth factor beta receptors: Homodimers form in the ER and persist at the plasma membrane;Gilboa;J. Cell Biol.,1998

5. How cells read TGF-beta signals;Massague;Nat. Rev. Mol. Cell Biol.,2000

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