TLR2 activation causes tachyphylaxis to β2-agonistsin vitroandex vivo:modelling bacterial exacerbation

Author:

Alkhouri H.1,Rumzhum N. N.1,Rahman M. M.1,FitzPatrick M.2,de Pedro M.3,Oliver B. G.3,Bourke J. E.24,Ammit A. J.1

Affiliation:

1. Faculty of Pharmacy; University of Sydney; Sydney NSW Australia

2. Respiratory Pharmacology Laboratory; Department of Pharmacology and Therapeutics; Lung Health Research Centre; University of Melbourne; Melbourne Vic. Australia

3. Woolcock Institute of Medical Research; University of Sydney; Sydney NSW Australia

4. Respiratory Pharmacology Laboratory; Department of Pharmacology; Monash University; Melbourne Vic. Australia

Funder

National Health and Medical Research Council

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference23 articles.

1. Rhinovirus and the lower respiratory tract;Hayden;Rev Med Virol,2004

2. Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study;Corne;Lancet,2002

3. The microbiology of asthma;Edwards;Nat Rev Microbiol,2012

4. Rhinovirus-induced exacerbations of asthma: how is the {beta}2-adrenoceptor implicated?;Trian;Am J Respir Cell Mol Biol,2010

5. Characterising the mechanism of airway smooth muscle β2 adrenoceptor desensitization by rhinovirus infected bronchial epithelial cells;Ly;PLoS Pathog,2013

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