Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts

Author:

Nielsen Natasja1,Pascal Veronique1,Fasth Andreas E. R.2,Sundström Yvonne2,Galsgaard Elisabeth D.3,Ahern David4,Andersen Martin15,Baslund Bo6,Bartels Else M.5,Bliddal Henning57,Feldmann Marc4,Malmström Vivianne2,Berg Louise2,Spee Pieter1,Söderström Kalle14

Affiliation:

1. Department of Translational Immunology; Novo Nordisk A/S; Måløv Denmark

2. Rheumatology Unit; Department of Medicine; Karolinska University Hospital; Stockholm Sweden

3. Department of Histology; Novo Nordisk A/S; Måløv Denmark

4. Kennedy Institute of Rheumatology; University of Oxford; London UK

5. The Parker Institute; Department of Rheumatology; Copenhagen University Hospital; Frederiksberg Denmark

6. Department of Rheumatology; Rigshospitalet; Copenhagen University Hospital; Copenhagen Denmark

7. Faculty of Health Sciences; University of Copenhagen; Copenhagen Denmark

Funder

Novo Nordisk

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference78 articles.

1. The pathogenesis of rheumatoid arthritis;McInnes;N Engl J Med,2011

2. Early synovitis-synoviocytes and mononuclear cells;Zvaifler;Semin Arthritis Rheum,1994

3. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice;Muller-Ladner;Am J Pathol,1996

4. Therapeutic opportunities in fibroblasts in inflammatory arthritis;Niedermeier;Best Pract Res Clin Rheumatol,2010

5. Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands;Pierer;J Immunol,2004

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