The dopaminergic alterations induced by 4‐F‐PCP and 4‐Keto‐PCP may enhance their drug‐induced rewarding and reinforcing effects: Implications for abuse

Author:

Ortiz Darlene Mae1,Custodio Raly James Perez1ORCID,Abiero Arvie12,Botanas Chrislean Jun13,Sayson Leandro Val1,Kim Mikyung4ORCID,Lee Hyun Jun1,Kim Hee Jin1ORCID,Jeong Youngdo5,Yoon Sulmin6,Lee Yong Sup5,Cheong Jae Hoon16

Affiliation:

1. Uimyung Research Institute for Neuroscience, Department of Pharmacy Sahmyook University Seoul Republic of Korea

2. Centre for Neuroscience and Regenerative Medicine, Faculty of Science University of Technology Sydney Ultimo New South Wales Australia

3. Department of Psychiatry University of Maryland School of Medicine Baltimore Maryland USA

4. Department of Chemistry and Life Science Sahmyook University Seoul Republic of Korea

5. Medicinal Chemistry Laboratory, Department of Pharmacy and Department of Life and Nanopharmaceutical Sciences, College of Pharmacy Kyung Hee University Seoul Republic of Korea

6. School of Pharmacy Jeonbuk National University Jeonju‐si Jeollabuk‐do Republic of Korea

Publisher

Wiley

Subject

Psychiatry and Mental health,Pharmacology,Medicine (miscellaneous)

Reference50 articles.

1. Novel psychoactive substances (designer drugs): overview and pharmacology of modulators of monoamine signaling;Liechtie M;Swiss Med,2015

2. Legal highs: staying on top of the flood of novel psychoactive substances

3. ‘Legal Highs’ – novel and emerging psychoactive drugs: a chemical overview for the toxicologist

4. United Nations Office on Drugs and Crimes 2017 Global Synthetic Drugs Assessment. Retrieved from:https://www.unodc.org/documents/scientific/Global_Drugs_Assessment_2017.pdf

5. 4‐MeO‐PCP and 3‐MeO‐PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels;Abiero A;Psychopharmacology (Berl),2019

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