1. Department of Genetics; Federal University of Pernambuco; Recife Brazil
2. Division of Haematology; Centre of Haematology and Haemotherapy of Ceara; Fortaleza Brazil
3. Department of Internal Medicine; Cancer Hospital of Pernambuco; Recife Brazil
4. Department of Internal Medicine; Haematology and Haemotherapy Foundation of Pernambuco; Recife Brazil