Proton pump inhibitors and the risk of acquiring a penicillin allergy label

Abstract

AbstractThe negative consequences of having a penicillin allergy label are well established. Penicillin allergy de‐labelling improves healthcare outcomes; however, less attention is paid to modifying risk factors leading to penicillin allergy development. In this propensity score‐matched retrospective cohort study, we used a de‐identified population‐based database (TriNetX Research Network) and examined the 30‐day risk of acquiring a penicillin allergy label in patients using proton pump inhibitors (PPIs). We demonstrated a higher risk of acquiring a penicillin allergy label among PPI users compared to controls.