The Bruton tyrosine kinase (BTK) inhibitor PCI-32765 synergistically increases proteasome inhibitor activity in diffuse large-B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) cells sensitive or resistant to bortezomib

Author:

Dasmahapatra Girija1,Patel Hiral1,Dent Paul,Fisher Richard I.2,Friedberg Jonathan2,Grant Steven

Affiliation:

1. Division of Hematology/Oncology; Department of Medicine; Virginia Commonwealth University; Richmond; VA; USA

2. Division of Hematology Oncology; University of Rochester Medical Center and the James P. Wilmot Cancer Center; Rochester; NY; USA

Publisher

Wiley

Subject

Hematology

Reference62 articles.

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2. Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts;An;Cell Death and Differentiation,1998

3. The Bruton's Tyrosine Kinase (BTK) Inhibitor PCI-32765 Inhibits Growth of ABC DLBCL Tumors In Vivo and in Vitro by Preventing Activation of Pro-Survival NF-{kappa}B pathways;Balbasubramanian;Blood (ASH annual Meeting Abstracts),2011

4. Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction;Bea;Blood,2005

5. Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets;Bedford;Nature reviews. Drug discovery,2011

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