The impact of genetic polymorphisms on the pharmacokinetics of efavirenz in African children

Author:

Bienczak Andrzej1,Cook Adrian2,Wiesner Lubbe1,Olagunju Adeniyi3,Mulenga Veronica4,Kityo Cissy5,Kekitiinwa Addy6,Owen Andrew3,Walker A. Sarah2,Gibb Diana M.2,McIlleron Helen1,Burger David7,Denti Paolo1

Affiliation:

1. Division of Clinical Pharmacology, Department of Medicine; University of Cape Town; Cape Town South Africa

2. MRC Clinical Trials Unit at University College London; London UK

3. Department of Molecular and Clinical Pharmacology; University of Liverpool; Liverpool UK

4. University Teaching Hospital, Department of Paediatrics and Child Health; Lusaka Zambia

5. Joint Clinical Research Centre; Kampala Uganda

6. Baylor College of Medicine Bristol Myers Squibb Children's Clinical Centre of Excellence, Kampala, Uganda / Gulu Regional Centre of Excellence; Gulu Uganda

7. Department of Pharmacy; Radboud University Nijmegen Medical Centre; Nijmegen the Netherlands

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference55 articles.

1. World Health Organization Antiretroviral therapy for HIV infection in infants and children: Towards universal access 2010 http://whqlibdoc.who.int/publications/2010/9789241599801_eng.pdf

2. Bristol-Myers Squibb SUMMARY OF PRODUCT CHARACTERISTICS - Sustiva http://www.ema.europa.eu/docs/pl_PL/document_library/EPAR_-_Product_Information/human/000249/WC500058311.pdf

3. Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients;Marzolini;AIDS,2001

4. Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study;Haas;AIDS,2004

5. Population pharmacokinetics and effects of efavirenz in patients with human immunodeficiency virus infection;Csajka;Clin Pharmacol Ther,2003

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