Promising tacrine/huperzine A‐based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget

Author:

Mak Shinghung12ORCID,Li Wenming3,Fu Hongjun4,Luo Jialie5,Cui Wei6,Hu Shengquan7,Pang Yuanping8,Carlier Paul R.9,Tsim Karl Wahkeung12,Pi Rongbiao10,Han Yifan11ORCID

Affiliation:

1. Shenzhen Key Laboratory of Edible and Medicinal Bioresources HKUST Shenzhen Research Institute Shenzhen China

2. Division of Life Science and Center for Chinese Medicine and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and Technology Hong Kong China

3. Department of Pharmacology and Chemical Biology Emory University School of Medicine Atlanta GA USA

4. Department of Neuroscience Chronic Brain Injury The Ohio State University Columbus OH USA

5. Department of Anesthesiology The Center for the Study of Itch and Sensory Disorders Washington University School of Medicine St. Louis MO USA

6. Zhejiang Provincial Key Laboratory of Pathophysiology Ningbo Key Laboratory of Behavioral Neuroscience School of Medicine Ningbo University Ningbo China

7. Shenzhen Institute of Geriatrics Shenzhen Second People's Hospital The First Affiliated Hospital of Shenzhen University Shenzhen China

8. Mayo Cancer Center Department of Pharmacology Mayo Clinic Rochester MN USA

9. Department of Chemistry Virginia Tech Blacksburg VA USA

10. Department of Pharmacology School of Medicine Sun Yat‐sen University Guangzhou China

11. Department of Applied Biology and Chemical Technology Institute of Modern Medicine The Hong Kong Polytechnic University Hong Kong China

Funder

National Institutes of Health

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

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