Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats

Author:

Nozu Tsukasa1,Miyagishi Saori2,Kumei Shima3,Nozu Rintaro1,Takakusaki Kaoru4,Okumura Toshikatsu23

Affiliation:

1. Department of Regional Medicine and Education; Asahikawa Medical University; Asahikawa Hokkaido Japan

2. Division of Gastroenterology and Hematology/Oncology, Department of Medicine; Asahikawa Medical University; Asahikawa Hokkaido Japan

3. Department of General Medicine; Asahikawa Medical University; Asahikawa Hokkaido Japan

4. Research Center for Brain Function and Medical Engineering; Asahikawa Medical University; Asahikawa Hokkaido Japan

Funder

Japan Society for the Promotion of Science KAKENHI, Grant-in-Aid for Scientific Research

Akiyama Life Science Foundation

Scientific Research on Innovative Areas

Publisher

Wiley

Subject

Gastroenterology,Hepatology

Reference40 articles.

1. A role for corticotropin-releasing factor in functional gastrointestinal disorders;Taché;Curr. Gastroenterol. Rep.,2009

2. Increased serum levels of lipopolysaccharide and antiflagellin antibodies in patients with diarrhea-predominant irritable bowel syndrome;Dlugosz;Neurogastroenterol. Motil.,2015

3. Irritable bowel syndrome immune hypothesis. Part two: the role of cytokines;Ortiz-Lucas;Rev. Esp. Enferm. Dig.,2010

4. Inflammation in irritable bowel syndrome: myth or new treatment target?;Sinagra;World J. Gastroenterol.,2016

5. Immune activation in patients with irritable bowel syndrome;Liebregts;Gastroenterology,2007

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