The ongoing challenge of discrepant growth hormone and insulin-like growth factor I results in the evaluation of treated acromegalic patients: a systematic review and meta-analysis

Author:

Kanakis G.A.1ORCID,Chrisoulidou A.2,Bargiota A.3,Efstathiadou Z.A.4,Papanastasiou L.5,Theodoropoulou A.6,Tigas S.K.7,Vassiliadi D.A.8,Tsagarakis S.9,Alevizaki M.10

Affiliation:

1. Department of Endocrinology; Athens Naval & VA Hospital; Athens Greece

2. Department of Endocrinology; Theagenio Cancer Hospital; Thessaloniki Greece

3. Department of Endocrinology and Metabolic Diseases; University of Thessaly; Larissa Greece

4. Department of Endocrinology; ‘Hippokration’ General Hospital of Thessaloniki; Thessaloniki Greece

5. Department of Endocrinology and Diabetes Center; Athens General Hospital ‘G. Gennimatas’; Athens Greece

6. Division of Endocrinology; Department of Internal Medicine; University Hospital of Patras; Rio Greece

7. Department of Endocrinology; University of Ioannina; Ioannina Greece

8. Endocrine Unit; 2nd Department of Internal Medicine - Propaedeutic; Research Institute and Diabetes Center; Attikon University Hospital; Medical School; National and Kapodistrian University of Athens; Athens Greece

9. Department of Endocrinology; Evangelismos Hospital; Athens Greece

10. Endocrine Unit; Department of Medical Therapeutics; Medical School; University of Athens; Athens Greece

Funder

Ipsen Fund

Publisher

Wiley

Subject

Endocrinology, Diabetes and Metabolism,Endocrinology

Reference30 articles.

1. A consensus on criteria for cure of acromegaly;Giustina;Journal of Clinical Endocrinology and Metabolism,2010

2. Discordant growth hormone and IGF-1 levels post pituitary surgery in patients with acromegaly naïve to medical therapy and radiation: what to follow, GH or IGF-1 values?;Brzana;Pituitary,2012

3. Divergence between growth hormone and insulin-like growth factor-i concentrations in the follow-up of acromegaly;Alexopoulou;Journal of Clinical Endocrinology and Metabolism,2008

4. Evaluation of disease status with sensitive measures of growth hormone secretion in 60 postoperative patients with acromegaly;Freda;Journal of Clinical Endocrinology and Metabolism,1998

5. Assessment of disease activity in treated acromegalic patients using a sensitive GH assay: should we achieve strict normal GH levels for a biochemical cure?;Costa;Journal of Clinical Endocrinology and Metabolism,2002

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