Adaptation of Subjective Responses to Alcohol is Affected by an Interaction ofGABRA2Genotype and Recent Drinking

Author:

Kosobud Ann E. K.1,Wetherill Leah23,Plawecki Martin H.4,Kareken David A.1,Liang Tiebing5,Nurnberger John L.4,Windisch Kyle3,Xuei Xiaoling6,Edenberg Howard J.26ORCID,Foroud Tatiana M.2,O'Connor Sean J.47

Affiliation:

1. Department of Neurology; Indiana University School of Medicine; Indianapolis Indiana

2. Department of Medical and Molecular Genetics; Indiana University School of Medicine; Indianapolis Indiana

3. Department of Psychology; Indiana University Purdue University at Indianapolis; Indianapolis Indiana

4. Department of Psychiatry; Indiana University School of Medicine; Indianapolis Indiana

5. Department of Medicine; Division of Endocrinology; Indiana University School of Medicine; Indianapolis Indiana

6. Department of Biochemistry and Molecular Biology; Indiana University School of Medicine; Indianapolis Indiana

7. R.L. Roudebush Veterans Administration Medical Center; Indianapolis Indiana

Funder

National Institute on Alcohol Abuse and Alcoholism

National Center for Research Resources

National Center for Advancing Translational Sciences

Publisher

Wiley

Subject

Psychiatry and Mental health,Toxicology,Medicine (miscellaneous)

Reference48 articles.

1. A GABRA2 variant is associated with increased stimulation and ‘high’ following alcohol administration;Arias;Alcohol Alcohol,2014

2. Alcohol dependence and genes encoding alpha2 and gamma1 GABAA receptor subunits: insights from humans and mice;Borghese;Alcohol Res,2012

3. Brown JD 2009 Principal components analysis and exploratory factor analysis-definitions, differences. and choices 26 30 http://jalt.org/test/PDF/Brown29.pdf

4. A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA;Bucholz;J Stud Alcohol,1994

5. Markers in the 5′-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene;Covault;Neuropsychopharmacology,2008

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