ALDH2 Deficiency Promotes Ethanol-Induced Gut Barrier Dysfunction and Fatty Liver in Mice

Author:

Chaudhry Kamaljit K.1,Samak Geetha1,Shukla Pradeep K.1,Mir Hina1,Gangwar Ruchika1,Manda Bhargavi1,Isse Toyohi2,Kawamoto Toshihiro2,Salaspuro Mikko3,Kaihovaara Pertti3,Dietrich Paula1,Dragatsis Ioannis1,Nagy Laura E.4,Rao Radha Krishna1

Affiliation:

1. Department of Physiology ; University of Tennessee; Memphis Tennessee

2. University of Occupational and Environmental Health ; Kitakyushu Japan

3. Res Unit Acetaldehyde and Cancer; University of Helsinki; Helsinki Finland

4. Cleveland Clinic Foundation ; Cleveland Ohio

Funder

NIH

Publisher

Wiley

Subject

Psychiatry and Mental health,Toxicology,Medicine (miscellaneous)

Reference39 articles.

1. Ethanol absorption across human skin measured by in vivo microdialysis technique;Anderson;Acta Derm Venereol,1991

2. Physiology and function of the tight junction;Anderson;Cold Spring Harb Perspect Biol,2009

3. Role of protein tyrosine phosphorylation in acetaldehyde-induced disruption of epithelial tight junctions;Atkinson;Am J Physiol Gastrointest Liver Physiol,2001

4. Acetaldehyde disrupts tight junctions and adherens junctions in human colonic mucosa: protection by EGF and L-glutamine;Basuroy;Am J Physiol Gastrointest Liver Physiol,2005

5. Jejunal microflora in patients with chronic alcohol abuse;Bode;Hepatogastroenterology,1984

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