Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice
Author:
Affiliation:
1. Department of Pharmacology, School of Medicine, Tsinghua University, Beijing, China
2. Institute of Biomechanics and Medical Engineering, School of Aerospace, Tsinghua University, Beijing, China
Abstract
Funder
National Natural Science Foundation of China
National Basic Research Program (973 Project) of China
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Link
http://academic.oup.com/jpp/article-pdf/65/12/1753/36385865/jphp12108.pdf
Reference10 articles.
1. Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease;Tanaka;Nat Med,2004
2. Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation;Rodríguez-Navarro;Neurobiol Dis,2010
3. Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases;Selkoe;Nat Cell Biol,2004
4. Metabolites of cerebellar neurons and hippocampal neurons play opposite roles in pathogenesis of Alzheimer's disease;Du;PLoS ONE,2009
5. Effect of trehalose on amyloid beta (29-40)-membrane interaction;Reddy;J Chem Phys,2009
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