Affiliation:
1. Department of Obstetrics and Gynaecology, Research Institute of Medical Science Konkuk University School of Medicine Seoul South Korea
2. Smart Healthcare Cancer Korea University Guro Hospital Seoul South Korea
3. Department of Obstetrics and Gynaecology Korea University College of Medicine Seoul South Korea
Abstract
AbstractObjectiveTo evaluate adverse obstetric outcomes in women with a history of endometrial cancer (EC).DesignPopulation‐based cohort study.SettingThe Korean National Health Insurance (KNHI) claims database.PopulationWomen who gave birth between 2009 and 2016, with a history of EC prior to pregnancy.MethodsThe KNHI database was used to compare obstetric outcomes of women with and without a history of EC, using the ICD‐10 codes. Multivariable logistic regression models were used to determine the associations between a history of EC and adverse obstetric outcomes.Main outcomes measuresAdverse obstetric outcomes.ResultsOverall, 248 and 3 335 359 women with and without a history of EC, respectively, gave birth. When adjusted for age, primiparity and comorbidities, an increased risk of multiple gestations (odds ratio [OR] 4.925, 95% confidence interval [CI] 3.394–7.147), caesarean delivery (OR 2.005, 95% CI 1.535–2.62) and preterm birth (OR 1.941, 95% CI 1.107–3.404) was observed among women with a history of EC. We were unable to demonstrate significant differences in the risk of pre‐eclampsia, gestational diabetes, vacuum delivery, placenta praevia, placenta accreta spectrum, placental abruption and postpartum haemorrhage between the groups. In the sensitivity analyses excluding multiple gestations, an increased risk of preterm birth was not observed among women with a history of EC (OR 1.276, 95% CI 0.565–2.881).ConclusionsThere is no convincing evidence of an increased risk of adverse obstetric outcomes among women with a history of EC. Our findings would be useful in counselling of patients with EC who are undergoing fertility‐sparing treatment.
Subject
Obstetrics and Gynecology
Cited by
1 articles.
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1. Obstetric outcomes in women with a history of endometrial cancer;BJOG: An International Journal of Obstetrics & Gynaecology;2023-11-08