Higher free testosterone in the third trimester was associated with lower abdominal circumference at birth in boys: Odense child cohort

Author:

Palm Camilla V. B.12ORCID,Dreyer Anja F.12ORCID,Boye Henriette34ORCID,Jørgensen Jan S.25ORCID,Wu Chunsen2ORCID,Højsager Frederik D.36ORCID,Jensen Tina K.346ORCID,Glintborg Dorte12ORCID,Andersen Marianne S.12ORCID

Affiliation:

1. Department of Endocrinology and Metabolism Odense University Hospital Odense Denmark

2. Department of Clinical Research, Faculty of Health Sciences University of Southern Denmark Odense Denmark

3. Odense Child Cohort, Hans Christian Andersen Hospital for Children and Adolescents Odense University Hospital Odense Denmark

4. OPEN Patient data Explorative Network (OPEN) University of Southern Denmark Odense Denmark

5. Department of Gynaecology and Obstetrics Odense University Hospital Odense Denmark

6. Department of Clinical Pharmacology, Pharmacy and Environmental Medicine University of Southern Denmark Odense Denmark

Abstract

AbstractObjectiveTo investigate associations between maternal testosterone status and offspring birth anthropometrics.DesignPopulation‐based prospective cohort study.SettingUniversity Hospital.Population1486 mother–child dyads from Odense Child Cohort.MethodsMaternal blood samples were collected at gestational weeks 27–30 and free testosterone (FT) levels were calculated using the Vermeulen equation from total testosterone (TT) analysed by mass spectrometry and sex hormone binding globulin. Associations between FT or TT levels and birth anthropometrics were analysed with multiple linear regression models according to offspring sex with adjustment for maternal age, parity, smoking and educational level. Analyses were repeated with polycystic ovary syndrome as exposure for offspring birth anthropometrics.Main outcome measuresOffspring birth weight (BW), birth length, abdominal and head circumferences.ResultsMaternal mean (SD) age was 30.2 (4.5) years and pre‐pregnancy body mass index was 23.5 (5.3) kg/m2. In boys (n = 787), higher FT was associated with lower birth weight (adjusted doubling constant = −65.53, P = 0.010), shorter birth length (adjusted doubling constant = −0.43, P < 0.001), and lower abdominal circumference (adjusted doubling constant = −0.39, P < 0.001); Higher TT was associated with lower abdominal circumference (adjusted doubling constant = −0.25, P = 0.028). In girls, no associations were found between maternal FT or TT and offspring anthropometrics.ConclusionsHigher maternal free testosterone exposure was linked to reduced birth weight, length and abdominal circumference in boys, whereas girls were not susceptible to maternal testosterone exposure.

Funder

Danmarks Frie Forskningsfond

Helsefonden

Lundbeckfonden

Novo Nordisk UK Research Foundation

Odense Universitetshospital

Region Syddanmark

Strategiske Forskningsråd

Syddansk Universitet

Publisher

Wiley

Subject

Obstetrics and Gynecology

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