Neonatal mortality risk of vulnerable newborns: A descriptive analysis of subnational, population‐based birth cohorts for 238 203 live births in low‐ and middle‐income settings from 2000 to 2017-Reference-Cited by-同舟云学术

Neonatal mortality risk of vulnerable newborns: A descriptive analysis of subnational, population‐based birth cohorts for 238 203 live births in low‐ and middle‐income settings from 2000 to 2017

Published:2023-05-08 Issue: Volume: Page:
ISSN:1470-0328
Container-title:BJOG: An International Journal of Obstetrics & Gynaecology
language:en
Short-container-title:BJOG

Author:

Hazel Elizabeth A.¹^ORCID,Erchick Daniel J.¹^ORCID,Katz Joanne¹,Lee Anne C. C.²^ORCID,Diaz Michael¹,Wu Lee S. F.¹,West Keith P.³,Shamim Abu Ahmed⁴,Christian Parul³,Ali Hasmot⁵,Baqui Abdullah H.⁶,Saha Samir K.⁷,Ahmed Salahuddin⁸,Roy Arunangshu Dutta⁸,Silveira Mariângela F.⁹,Buffarini Romina⁹,Shapiro Roger¹⁰,Zash Rebecca¹¹,Kolsteren Patrick¹²,Lachat Carl¹²,Huybregts Lieven¹²¹³,Roberfroid Dominique¹⁴¹⁵,Zhu Zhonghai¹⁶,Zeng Lingxia¹⁶,Gebreyesus Seifu H.¹⁷,Tesfamariam Kokeb¹⁸,Adu‐Afarwuah Seth¹⁹,Dewey Kathryn G.²⁰,Gyaase Stephaney²¹,Poku‐Asante Kwaku²¹,Boamah Kaali Ellen²¹²²,Jack Darby²³,Ravilla Thulasiraj²⁴,Tielsch James²⁵,Taneja Sunita²⁶,Chowdhury Ranadip²⁶,Ashorn Per²⁷,Maleta Kenneth²⁸,Ashorn Ulla²⁹,Mangani Charles²⁸,Mullany Luke C.¹,Khatry Subarna K.³⁰,Ramokolo Vundli³¹³²,Zembe‐Mkabile Wanga³³³⁴,Fawzi Wafaie W.¹⁰,Wang Dongqing³⁵,Schmiegelow Christentze³⁶^ORCID,Minja Daniel³⁷,Msemo Omari Abdul³⁷,Lusingu John P. A.³⁷,Smith Emily R.³⁸,Masanja Honorati³⁹,Mongkolchati Aroonsri⁴⁰,Keentupthai Paniya⁴¹,Kakuru Abel⁴²,Kajubi Richard⁴²,Semrau Katherine⁴³⁴⁴⁴⁵^ORCID,Hamer Davidson H.⁴⁶⁴⁷,Manasyan Albert⁴⁸,Pry Jake M.⁴⁹^ORCID,Chasekwa Bernard⁵⁰,Humphrey Jean¹,Black Robert E.¹, ,

Affiliation:

1. International Health Department Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA

2. Pediatric Newborn Medicine Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA

3. Department of International Health, Center for Human Nutrition Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA

4. BRAC JP Grant School of Public Health Dhaka Bangladesh

5. JiVitA Maternal and Child Health Research Project Rangpur Bangladesh

6. Department of International Health Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA

7. Child Health Research Foundation Dhaka Bangladesh

8. Projahnmo Research Foundation Dhaka Bangladesh

9. Post‐Graduate Program in Epidemiology – Federal University of Pelotas Pelotas Brazil

10. Harvard T.H. Chan School of Public Health Boston Massachusetts USA

11. Beth Israel Deaconess Medical Center Boston Massachusetts USA

12. Department of Food Technology, Safety and Health Ghent University Ghent Belgium

13. Poverty, Health and Nutrition Division International Food Policy Research Institute Washington District of Columbia USA

14. Namur University Namur Belgium

15. Belgian Health Care Knowledge Centre Brussels Belgium

16. Department of Epidemiology and Biostatistics, School of Public Health Xi'an Jiaotong University Health Science Centre Xi'an China

17. Department of Nutrition and Dietetics, School of Public Health Addis Ababa University Addis Ababa Ethiopia

18. Department of Food Technology, Safety, and Health, Faculty of Bioscience Engineering Ghent University Ghent Belgium

19. Department of Nutrition and Food Science University of Ghana Accra Ghana

20. Department of Nutrition, Institute for Global Nutrition University of California Davis California USA

21. Kintampo Health Research Centre Kintampo Ghana

22. Research and Development Division Ghana Health Service Accra Ghana

23. Columbia University's Mailman School of Public Health New York New York USA

24. Aravind Eye Hospital Madurai India

25. George Washington University Milken Institute School of Public Health Washington District of Columbia USA

26. Centre for Health Research and Development Society for Applied Studies New Delhi India

27. Faculty of Medicine and Health Technology Tampere University and Tampere University Hospital Tampere Finland

28. School of Global and Public Health Kamuzu University of Health Sciences Blantyre Malawi

29. Faculty of Medicine and Health Technology Tampere University Tampere Finland

30. NNIPS Kathmandu Nepal

31. HIV and Other Infectious Diseases Research Unit South African Medical Research Council Cape Town South Africa

32. Gertrude H Sergievsky Center, Vagelos College of Physicians and Surgeons Columbia University Irving Medical Center New York New York USA

33. Health Systems Research Unit South African Medical Research Council Cape Town South Africa

34. South African Research Chair in Social Policy at College Graduate of Studies University of South Africa Pretoria South Africa

35. Department of Global and Community Health, College of Public Health George Mason University Fairfax Virginia USA

36. Centre for Medical Parasitology Department of Immunology and Microbiology, University of Copenhagen, and Department of Infectious Diseases, Copenhagen University Hospital Copenhagen Denmark

37. National Institute of Medical Research Tanga Tanzania

38. Department of Global Health Milken Institute School of Public Health Washington District of Columbia USA

39. Ifakara Health Institute Dar es Salaam Tanzania

40. ASEAN Institute for Health Development Mahidol University Salaya Thailand

41. College of Medicine and Public Health Ubon Ratchathani University Ubon Ratchathani Thailand

42. Infectious Diseases Research Collaboration Kampala Uganda

43. Ariadne Labs Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health Boston Massachusetts USA

44. Division of Global Health Equity, Department of Medicine Brigham and Women's Hospital Boston Massachusetts USA

45. Department of Medicine Harvard Medical School Boston Massachusetts USA

46. Department of Global Health Boston University School of Public Health Boston Massachusetts USA

47. Section of Infectious Diseases, Department of Medicine Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA

48. University of Alabama at Birmingham Birmingham Alabama USA

49. Centre for Infectious Disease Research in Zambia Lusaka Zambia

50. Zvitambo Institute for Maternal and Child Health Research Harare Zimbabwe

Abstract

AbstractObjectiveWe aimed to understand the mortality risks of vulnerable newborns (defined as preterm and/or born weighing smaller or larger compared to a standard population), in low‐ and middle‐income countries (LMICs).DesignDescriptive multi‐country, secondary analysis of individual‐level study data of babies born since 2000.SettingSixteen subnational, population‐based studies from nine LMICs in sub‐Saharan Africa, Southern and Eastern Asia, and Latin America.PopulationLive birth neonates.MethodsWe categorically defined five vulnerable newborn types based on size (large‐ or appropriate‐ or small‐for‐gestational age [LGA, AGA, SGA]), and term (T) and preterm (PT): T + LGA, T + SGA, PT + LGA, PT + AGA, and PT + SGA, with T + AGA (reference). A 10‐type definition included low birthweight (LBW) and non‐LBW, and a four‐type definition collapsed AGA/LGA into one category. We performed imputation for missing birthweights in 13 of the studies.Main Outcome MeasuresMedian and interquartile ranges by study for the prevalence, mortality rates and relative mortality risks for the four, six and ten type classification.ResultsThere were 238 203 live births with known neonatal status. Four of the six types had higher mortality risk: T + SGA (median relative risk [RR] 2.6, interquartile range [IQR] 2.0–2.9), PT + LGA (median RR 7.3, IQR 2.3–10.4), PT + AGA (median RR 6.0, IQR 4.4–13.2) and PT + SGA (median RR 10.4, IQR 8.6–13.9). T + SGA, PT + LGA and PT + AGA babies who were LBW, had higher risk compared with non‐LBW babies.ConclusionsSmall and/or preterm babies in LIMCs have a considerably increased mortality risk compared with babies born at term and larger. This classification system may advance the understanding of the social determinants and biomedical risk factors along with improved treatment that is critical for newborn health.

Funder

Children's Investment Fund Foundation

Publisher

Wiley

Subject

Obstetrics and Gynecology

Link

https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1111/1471-0528.17518

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