NNC-711: An Inhibitor of GAB A Uptake with Selective Affinity to GAT-1
Author:
Publisher
Wiley
Subject
Pharmacology,Neuropsychology and Physiological Psychology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1527-3458.1999.tb00108.x/fullpdf
Reference52 articles.
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2. The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-bute-nyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate;Andersen;J Med Chem,1993
3. Nonvesicular release of neurotransmitter;Attwell;Neuron,1993
4. GABA uptake blocker NNC-711 exhibits marked anticonvulsant action in two cortical epileptic models in epileptic rats;Bernášková;Epilepsia,1999
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1. Upregulation of the GABA-transporter GAT-1 in the spinal cord contributes to pain behaviour in experimental neuropathy;Neuroscience Letters;2008-10
2. Increased γ-Aminobutyric Acid Levels in Mouse Brain Induce Loss of Righting Reflex, but Not Immobility, in Response to Noxious Stimulation;Anesthesia & Analgesia;2007-06
3. Antidystonic efficacy of γ-aminobutyric acid uptake inhibitors in the dt mutant;European Journal of Pharmacology;2005-10
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