Progress and perspective of trained immunity in teleost fish

Author:

You Xinwei1,Yang Jin1,Wang Zhuang1,Wang Qiyao1,Liu Qin1,Zhang Yuanxing1,Wiegertjes Geert F.2,Yang Dahai1ORCID

Affiliation:

1. State Key Laboratory of Bioreactor Engineering, Laboratory for Aquatic Animal Diseases East China University of Science and Technology Shanghai China

2. Aquaculture and Fisheries Group Wageningen University & Research Wageningen The Netherlands

Abstract

AbstractTrained immunity defines the long‐term memory of innate immunity based on innate immune signalling, metabolic changes and epigenetic rewiring of trained innate immune cells, which are characterised by elevated inflammatory responses towards secondary stimuli. The activation of this non‐specific protection‐mediated memory in innate immune cells was identified to benefit host defences as well as play a detrimental role in inflammatory diseases. In this review, we focused on summing up the current progress about the inducers, effector cells, molecular mechanisms and protective effects of trained immunity that have been identified in both mammals and teleost fish, and discussing the future research and application of trained immunity in aquaculture. Revealing the mechanisms of trained immunity will not only provide a novel aspect for understanding the evolution of innate immune memory and their longer‐term protections, but also contribute to the rational design and evaluation of immunopotentiators, adjuvants and potential vaccines in aquaculture.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Fundamental Research Funds for the Central Universities

Publisher

Wiley

Subject

Management, Monitoring, Policy and Law,Ecology,Aquatic Science

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