Formation of <scp>CYP3A</scp> ‐specific metabolites of ibrutinib in vitro is correlated with hepatic <scp>CYP3A</scp> activity and 4β‐hydroxycholesterol/cholesterol ratio-Reference-Cited by-同舟云学术

Formation of CYP3A ‐specific metabolites of ibrutinib in vitro is correlated with hepatic CYP3A activity and 4β‐hydroxycholesterol/cholesterol ratio

Published:2022-11-23 Issue:2 Volume:16 Page:279-291
ISSN:1752-8054
Container-title:Clinical and Translational Science
language:en
Short-container-title:Clinical Translational Sci

Author:

Lee Jonghwa¹,Fallon John K.²^ORCID,Smith Philip C.²^ORCID,Jackson Klarissa D.¹^ORCID

Affiliation:

1. Division of Pharmacotherapy and Experimental Therapeutics University of North Carolina at Chapel Hill Eshelman School of Pharmacy Chapel Hill North Carolina USA

2. Division of Pharmacoengineering and Molecular Pharmaceutics University of North Carolina at Chapel Hill Eshelman School of Pharmacy Chapel Hill North Carolina USA

Funder

National Institutes of Health

National Institute of General Medical Sciences

North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill

Georgia Clinical and Translational Science Alliance

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cts.13448

Reference45 articles.

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2. Ibrutinib versus temsirolimus in patients with relapsed or refractory mantle-cell lymphoma: an international, randomised, open-label, phase 3 study

3. Bruton Tyrosine Kinase Inhibitor Ibrutinib (PCI-32765) Has Significant Activity in Patients With Relapsed/Refractory B-Cell Malignancies

4. Absorption, Metabolism, and Excretion of Oral 14C Radiolabeled Ibrutinib: An Open-Label, Phase I, Single-Dose Study in Healthy Men

5. Ibrutinib (imbruvica): a novel targeted therapy for chronic lymphocytic leukemia;Parmar S;P T,2014

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