siRNA Mediated Knockdown of Tissue Factor Expression in Pigs for Xenotransplantation

Author:

Ahrens H. E.1,Petersen B.1,Herrmann D.1,Lucas-Hahn A.1,Hassel P.1,Ziegler M.1,Kues W. A.1,Baulain U.1,Baars W.2,Schwinzer R.2,Denner J.3,Rataj D.4,Werwitzke S.4,Tiede A.4,Bongoni A. K.5,Garimella P. S.5,Despont A.5,Rieben R.5,Niemann H.1

Affiliation:

1. Institute of Farm Animal Genetics; Friedrich-Loeffler-Institut; Mariensee Neustadt Germany

2. Transplant Laboratory; Clinic for General, Visceral, and Transplant Surgery, Hannover Medical School; Hannover Germany

3. Robert Koch Institute; Berlin Germany

4. Department of Hematology; Hemostasis, Oncology and Stem Cell Transplantation, Medical School Hanover; Hannover Germany

5. Department of Clinical Research; University of Bern; Bern Switzerland

Publisher

Wiley

Subject

Pharmacology (medical),Transplantation,Immunology and Allergy

Reference29 articles.

1. Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients;Dalmasso;Am J Pathol,1992

2. Progress in pig-to-non-human primate transplantation models (1998-2013): A comprehensive review of the literature;Cooper;Xenotransplantation,2014

3. Activation of factor IX by the reaction product of tissue factor and factor VII: Additional pathway for initiating blood coagulation;Osterud;Proc Natl Acad Sci USA,1977

4. Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis;Mueller;Proc Natl Acad Sci USA,1992

5. Tissue factor expression during human and mouse development;Luther;Am J Pathol,1996

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