Role of CXCR5+CD8+ T cells in human hepatitis B virus infection

Author:

Zhou Juan1,He Xiaojing1,Ou Yangjing1,Peng Shuang1,Li Dan1,Zhou Qing1,Fu Jingli1,Long Yunzhu1,Tan Yingzheng1

Affiliation:

1. Department of Infectious Diseases, Zhuzhou Hospital Affiliated to Xiangya School of Medicine Central South University Zhuzhou China

Abstract

AbstractThe replication of HBV in hepatocytes can be effectively inhibited by lifelong antiviral therapy. Because of the long‐term presence of HBV reservoirs, the virus rebound frequently occurs once the treatment is stopped, which poses a considerable obstacle to the complete removal of the virus. In terms of gene composition, regulation of B cell action and function, CXCR5+CD8+ T cells are similar to CXCR5+CD4+ T follicular helper cells, while these cells are characterized by elevated programmed cell death 1 and cytotoxic‐related proteins. CXCR5+CD8+T cells are strongly associated with progression in inflammatory and autoimmune diseases. In addition, CXCR5 expression on the surface of CD8+ T cells is mostly an indicator of memory stem cell‐like failure in progenitor cells in cancer that are more responsive to immune checkpoint blocking therapy. Furthermore, the phenomena have also been demonstrated in some viral infections, highlighting the duality of the cellular immune response of CXCR5+CD8+ T cells. This mini‐review will focus on the function of CXCR5+CD8+ T cells in HBV infection and discuss the function of these CD8+ T cells and the potential of associated co‐stimulators or cytokines in HBV therapeutic strategies.

Funder

Health Commission of Hunan Province

Publisher

Wiley

Subject

Virology,Infectious Diseases,Hepatology

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