Adrenal limb thickness is associated with metabolism profiles in patients with diabetes: A cross‐sectional study

Author:

Liu Yingning1,Zou Xiantong1,Zhao Wei12,Yao Xun2,Wang Lexuan3,Zhou LingLi1,Zhang Rui1ORCID,Luo Yingying1,Li Meng1ORCID,Zhang Xiuying1,Zhu Yu1,Cai Xiaoling1,Zhou Xianghai1,Han Xueyao1,Ji Linong1ORCID

Affiliation:

1. Department of Endocrinology and Metabolism Peking University People's Hospital Beijing China

2. Department of Radiology Peking University People's Hospital Beijing China

3. School of Basic Medical Sciences Peking University Beijing China

Abstract

AbstractBackgroundThe association between adrenal size and metabolic profiles in patients with diabetes mellitus (DM) is unclear. This study was conducted to determine whether the adrenal thickness measured by computed tomography (CT) is correlated with the metabolic profiles of patients with DM.MethodsThis was a cross‐sectional study including 588 Chinese hospitalized patients with DM without comorbidities or medications known to affect adrenal morphology or hormone secretion. Adrenal limb thickness was measured on unenhanced chest CT. Participants were stratified into tertiles according to their total adrenal limb thickness. Linear and logistic regression models were used to estimate the correlations.ResultsAfter adjustment for sex and age, the adrenal thickness was positively associated with body mass index (BMI), waist circumference (WC), urinary albumin/creatinine ratio, and 24‐h urinary free cortisol (UFC) and negatively correlated with high‐density lipoprotein cholesterol. The sequential equation model (SEM) suggested UFC partially mediated the effect of adrenal limb thickness on WC by 12%. Adrenal thickness, but not UFC, was associated with a higher risk of existing hypertension (odds ratio [OR] = 3.78, 95% confidence interval [CI] 1.58, 9.02) and hyperlipidemia (OR = 2.76, 95% CI 1.03, 7.38), independent of age, gender, BMI, and WC.ConclusionsThe adrenal thickness is independently associated with BMI, WC, cortisol levels, urinary albumin/creatinine ratio, hypertension, and dyslipidemia but not glycemic parameters in patients with diabetes. Our study encourages further studies to investigate the role of adrenal physiology in patients with diabetes.

Funder

Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park

National Natural Science Foundation of China

Publisher

Wiley

Subject

Endocrinology, Diabetes and Metabolism

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