Steady state is reached within 2-3 days of once-daily administration of degludec, a basal insulin with an ultralong duration of action
Author:
Affiliation:
1. Profil; Neuss Germany
2. Medical University of Graz; Graz Austria
3. Novo Nordisk A/S; Søborg Denmark
4. Aalborg Denmark
5. Profil Institute for Clinical Research; Chula Vista California USA
Funder
Novo Nordisk
Publisher
Wiley
Subject
Endocrinology, Diabetes and Metabolism
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/1753-0407.12266/fullpdf
Reference24 articles.
1. Towards peakless, reproducible and long-acting insulins. An assessment of the basal analogues based on isoglycaemic clamp studies;Heise;Diabetes Obes Metab,2007
2. To: Scholtz HE, Pretorius SG, Wessels DH, Becker RHA (2005) pharmacokinetic and glucodynamic variability: assessment of insulin glargine, NPH insulin and insulin ultralente in healthy volunteers using a euglycaemic clamp technique. Diabetologia 48: 1988-1995;Devries;Diabetologia,2006
3. Binding of phenol to R6 insulin hexamers;Berchtold;Biopolymers,1999
4. Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes;Heise;Diabetes,2004
5. Insulin degludec: Four times lower pharmacodynamic variability than insulin glargine under steady-state conditions in type 1 diabetes;Heise;Diabetes Obes Metab,2012
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