Extracellular matrix is modulated in advanced glycation end products milieu via a RAGE receptor dependent pathway boosted by transforming growth factor‐ β 1 在晚期糖基化终末产物环境中细胞外基质通过RAGE受体依赖性途径调节,转化生长因子‐ β 1可以促进这种调节
Author:
Affiliation:
1. Department of Preclinical SciencesUniversity of Agronomical Sciences and Veterinary Medicine Bucharest Romania
2. Department of Biochemistry and Molecular BiologyUniversity of Bucharest Bucharest Romania
Funder
Romanian National Authority for Scientific Research, CNCS-UEFISCDI
Publisher
Wiley
Subject
Endocrinology, Diabetes and Metabolism
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/1753-0407.12154
Reference43 articles.
1. RAGE‐ and TGF‐ β receptor‐mediated signals converge on STAT5 and p21wafto control cell‐cycle progression of mesangial cells: a possible role in the development and progression of diabetic nephropathy
2. Metabolic syndrome and chronic kidney disease
3. Gelatinase A (MMP-2) Is Necessary and Sufficient for Renal Tubular Cell Epithelial-Mesenchymal Transformation
4. Advanced Glycation End Products Induce Tubular Epithelial-Myofibroblast Transition through the RAGE-ERK1/2 MAP Kinase Signaling Pathway
5. Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation
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