Affiliation:
1. Department of Surgery Division of Urology Human Reproduction Section São Paulo Federal University São Paulo Brazil
Abstract
AbstractBackgroundVaricocele is one of the main causes of male infertility. Although the pathophysiology mechanism of varicocele is very well described and understood, there are some unanswered questions that remains unknown. Some studies have previously described the state of testicular inflammation and sperm in animal models, especially the mouse model, and the seminal plasma of men with varicocele, with or without changes in semen parameters.Methods of studyThis review intended to verify the role of inflammatory mechanism in varicocele, using clinical studies as well as animal model studies on the effect of inflammation caused by varicocele on the function of testicular somatic and germ cells.ResultsIn‐vivo studies confirmed whether anti‐inflammatory molecules could treat the semen of men with varicocele and rats with varicocele. The use of different anti‐inflammatory agents in mouse model studies provided a new perspective for future clinical studies to investigate the effect of concurrent treatment with surgery to improve surgical outcomes.ConclusionSimilar to animal model studies, previously conducted clinical trials have demonstrated the effectiveness of anti‐inflammatory therapy in varicocele patients. However, clinical trials using anti‐inflammatory are needed to be conducted agents to evaluate different aspects of this therapeutical approach in varicocele patients.
Funder
Fundação de Amparo à Pesquisa do Estado de São Paulo
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Subject
Obstetrics and Gynecology,Reproductive Medicine,Immunology,Immunology and Allergy,Obstetrics and Gynecology,Immunology