Microsecond molecular dynamics simulations provide insight into the ATP-competitive inhibitor-induced allosteric protection of Akt kinase phosphorylation-Reference-Cited by-同舟云学术

Microsecond molecular dynamics simulations provide insight into the ATP-competitive inhibitor-induced allosteric protection of Akt kinase phosphorylation

Published:2016-11-24 Issue:5 Volume:89 Page:723-731
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Mou Linkai¹,Cui Tongwei¹,Liu Weiguang¹,Zhang Hong¹,Cai Zhanxiu²,Lu Shaoyong³,Gao Guojun¹

Affiliation:

1. Department of Urology; Affiliated Hospital of Weifang Medical University; Weifang Shandong China

2. Department of Electrical and Computer Engineering; College of Bioscience and Technology; Weifang Medical University; Weifang Shandong China

3. Department of Pathophysiology; School of Medicine; Shanghai Jiao Tong University; Shanghai China

Funder

Shanghai Health and Family Planning Commission

Science and Technology Pillar Program of Shandong

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12895/fullpdf

Reference49 articles.

1. AKT/PKB Signaling: Navigating Downstream

2. Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer

3. Structure, regulation and function of PKB/AKT—a major therapeutic target

4. The nuts and bolts of AGC protein kinases

5. Ras Conformational Ensembles, Allostery, and Signaling

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