In vitro and in vivo effects of MK2206 and chloroquine combination therapy on endometriosis: autophagy may be required for regrowth of endometriosis
Author:
Affiliation:
1. Chirurgie Gynécologique; CHU Clermont-Ferrand; Clermont-Ferrand France
2. Institut Pascal, UMR6602; Université Clermont Auvergne, CNRS/UCA/SIGMA; Clermont-Ferrand France
Funder
Karl Storz Endoscopy & GmbH
Publisher
Wiley
Subject
Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bph.14170/fullpdf
Reference62 articles.
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3. Autophagy: assays and artifacts;Barth;J Pathol,2010
4. Combining AKT inhibition with chloroquine and gefitinib prevents compensatory autophagy and induces cell death in EGFR mutated NSCLC cells;Bokobza;Oncotarget,2014
5. MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis;Cheng;Mol Cancer Ther,2012
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