A phase I evaluation of the effect of curcumin on dose‐limiting toxicity and pharmacokinetics of irinotecan in participants with solid tumors-Reference-Cited by-同舟云学术

A phase I evaluation of the effect of curcumin on dose‐limiting toxicity and pharmacokinetics of irinotecan in participants with solid tumors

Published:2022-02-26 Issue:5 Volume:15 Page:1304-1315
ISSN:1752-8054
Container-title:Clinical and Translational Science
language:en
Short-container-title:Clinical Translational Sci

Author:

Gbolahan Olumide B.¹,O’Neil Bert H.²,McRee Autumn J.³,Sanoff Hanna K.³,Fallon John K.⁴,Smith Philip C.⁴,Ivanova Anastasia⁵,Moore Dominic T.⁵,Dumond Julie⁶,Asher Gary N.⁷

Affiliation:

1. Division of Hematology and Oncology University of Alabama School of Medicine University of Alabama at Birmingham Birmingham Alabama USA

2. Community North Cancer Center Indianapolis Indiana USA

3. Division of Hematology and Oncology UNC School of Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina USA

4. Division of Pharmacoengineering and Molecular Pharmaceutics UNC Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina USA

5. Department of Biostatistics UNC Gillings School of Public Health University of North Carolina at Chapel Hill Chapel Hill North Carolina USA

6. Division of Pharmacotherapy and Experimental Therapeutics UNC Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina USA

7. Department of Family Medicine UNC School of Medicine University of North Carolina Chapel Hill North Carolina USA

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cts.13250

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5. Nuclear factor-?B and I?B kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis

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