Unravelling the suboptimal response ofTP53-mutated chronic lymphocytic leukaemia to ibrutinib

Author:

Guarini Anna1,Peragine Nadia2,Messina Monica2ORCID,Marinelli Marilisa2,Ilari Caterina2,Cafforio Luciana2,Raponi Sara2ORCID,Bonina Silvia2,Mariglia Paola2,Mauro Francesca R.2ORCID,Gaidano Gianluca3,Del Giudice Ilaria2ORCID,Foà Robin2

Affiliation:

1. Department of Molecular Medicine; “Sapienza” University; Rome Italy

2. Department of Cellular Biotechnologies and Haematology; “Sapienza” University; Rome Italy

3. Department of Translational Medicine; Amedeo Avogadro University of Eastern Piedmont; Novara Italy

Funder

Associazione Italiana per la Ricerca sul Cancro

Special Program Molecular Clinical Oncology

Ricerca Finalizzata

Ministry of Health

Progetti di Rilevante Interesse Nazionale

Publisher

Wiley

Subject

Hematology

Reference15 articles.

1. Cell-intrinsic determinants of ibrutinib-induced apoptosis in chronic lymphocytic leukemia;Amin;Clinical Cancer Research,2017

2. Extended follow-up and impact of high-risk prognostic factors from the phase 3 RESONATE study in patients with previously treated CLL/SLL;Brown;Leukemia,2017

3. Ibrutinib as initial therapy for patients with chronic lymphocytic leukemia;Burger;New England Journal of Medicine,2015

4. Leukemia cell proliferation and death in chronic lymphocytic leukemia patients on therapy with the BTK inhibitor ibrutinib;Burger;Journal of Clinical Investigation Insight,2017

5. Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinib;Byrd;Blood,2015

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