Soluble polyvinylpyrrolidone‐based microneedles loaded with Sanguis draconis and Salvia miltiorrhiza for treatment of diabetic wound healing

Abstract

AbstractBackgroundNowadays, diabetic wound healing remains a crucial challenge due to their protracted and uncertain healing process. Traditional Chinese medicine (TCM) has demonstrated the therapeutic value of Sanguis draconis (SD)‐Salvia miltiorrhiza (SMR) Herb Pair in diabetic wound healing. However, new administration modes are urgently needed for their convenient and wide‐ranging applications.ObjectiveWe propose a soluble polyvinylpyrrolidone‐based microneedle patch containing the herbal extracts of SD and SMR (MN‐SD@SMR) for diabetic wound healing.MethodsThe herbal extracts of SD and SMR are purification and concentration via traditional lyophilization. SD endowed MN‐SD@SMR with functions to improve high glycemic blood environment and migration of keratinocyte and fibroblast cells.ResultsSMR in MN‐SD@SMR could improve blood flow velocity and microcirculation in the wound area. The effectiveness of transdermal release and mechanical strengths of MN‐SD@SMR were verified.ConclusionIntegrating the advantages of these purified herbal compositions, we demonstrated that MN‐SD@SMR had a positive healing effect on the wounds in vitro and vivo. These results indicate that soluble polyvinylpyrrolidone‐based microneedle patch containing the herbal extracts of SD and SMR has a promising application value due to their superior capability to promote diabetic wound healing.