Affiliation:
1. Division of Allergy and Clinical Immunology, Department of medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society Bangkok Thailand
2. Department of Medicine, Division of Dermatology Phramongkutklao Hospital Bangkok Thailand
3. The Skin and Allergy Research Unit Chulalongkorn University Bangkok Thailand
Abstract
AbstractVitamin D deficiency has been reported to be associated with allergic diseases and dermatological disorders. We investigated the role of vitamin D in drug‐induced non‐immediate hypersensitivity reactions by measuring serum vitamin D levels in 60 patients diagnosed with non‐immediate drug hypersensitivity reactions and in 60 patients who tolerated the same medication without any allergic reactions. The results showed that serum vitamin D levels were significantly lower in patients with severe cutaneous adverse reactions (SCARs) (13.56 ± 6.23 ng/mL) compared to patients with mild reactions (17.50 ± 7.49 ng/mL) and the drug‐tolerant control group (17.42 ± 7.28 ng/mL), with p values of 0.031 and 0.015, respectively. The proportion of severe vitamin D deficiency (< 10 ng/mL) was much higher in SCAR patients compared to drug‐tolerant subjects (36.7% vs. 11.7%, p value = 0.005). After adjusting for age, gender, region of residence, and concurrent illnesses, patients with severe vitamin D deficiency had significantly increased in‐hospital mortality (odds ratio 16.04; 95% CI, 1.25–206.12, p value = 0.03). In conclusion, the risk of developing SCARs and in‐hospital mortality was increased in patients with severe vitamin D deficiency. Further investigations should be conducted to elucidate the role of vitamin D in the development of SCARs.
Subject
Dermatology,Molecular Biology,Biochemistry