Hypoxia-induced relaxation of porcine retinal arteriolesin vitrodepends on inducible NO synthase and EP4receptor stimulation in the perivascular retina

Author:

Oversø Hansen Pernille1,Kringelholt Sidse1,Simonsen Ulf2,Bek Toke1

Affiliation:

1. Department of Ophthalmology; Aarhus University Hospital; Aarhus Denmark

2. Department of Biomedicine; University of Aarhus; Aarhus Denmark

Funder

Aarhus Universitets Forskningsfond

Reventlow Poulsen´s Foundation

The Danish Medical Research Council

VELUX Foundation

Publisher

Wiley

Subject

Ophthalmology,General Medicine

Reference37 articles.

1. Nitric oxide synthases: structure, function and inhibition;Alderton;Biochem J,2001

2. SCORE Study Report #11: incidences of neovascular events in eyes with retinal vein occlusion;Chan;Ophthalmology,2011a

3. Endothelium-derived NO, but not cyclic GMP, is required for hypoxic augmentation in isolated porcine coronary arteries;Chan;Am J Physiol Heart Circ Physiol,2011b

4. Ibuprofen enhances retinal and choroidal blood flow autoregulation in newborn piglets;Chemtob;Invest Ophthalmol Vis Sci,1991

5. Role of interleukin-1β in hypoxia-induced depression of glutamate uptake in retinal Müller cells;Chen;Graefes Arch Clin Exp Ophthalmol,2014

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