A win‐win platform: Stabilized black phosphorous nanosheets loading gallium ions for enhancing the healing of bacterial‐infected wounds through synergistic antibacterial approaches

Author:

Li Zhiwei1,Ren Jiwei1,Sui Xin1,Yang Nan1,Li Sijia1,Qi Le1,Li Sining1,Fan Yixin1,Liu Zhihui1

Affiliation:

1. Department of Prosthodontics, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School of Stomatology Jilin University Changchun China

Abstract

AbstractBacterial infection is the most common complication in wound healing, highlighting an urgent need for the development of innovative antibacterial technologies and treatments to address the growing threats posed by bacterial infections. Black phosphorus nanosheets (BPNSs), as a promising two‐dimensional nanomaterial, have been utilized in treating infected wounds. However, BP's limited stability restricts its application. In this study, we enhance BP's stability and its antibacterial properties by anchoring gallium ions (Ga3+) onto BP's surface, creating a novel antibacterial platform. This modification reduces BP's electron density and enhances its antibacterial capabilities through a synergistic effect. Under near‐infrared (NIR) irradiation, the BP/Ga3+ combination exerts antibacterial effects via photothermal therapy (PTT) and photodynamic therapy (PDT), while also releasing Ga3+. The Ga3+ employ a ‘Trojan horse strategy’ to disrupt iron metabolism, significantly boosting the antibacterial efficacy of the complex. This innovative material offers a viable alternative to antibiotics and holds significant promise for treating infected wounds and aiding skin reconstruction.

Funder

Department of Finance of Jilin Province

Department of Science and Technology of Jilin Province

Publisher

Wiley

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