Synthetic biology: at the crossroads of genetic engineering and human therapeutics—a Keystone Symposia report

Author:

Cable Jennifer1,Leonard Joshua N.2,Lu Timothy K.34,Xie Zhen5,Chang Matthew Wook6,Fernández Luis Ángel7,Lora José M.8,Kaufman Howard L.9,Quintana Francisco J.10,Geiger Roger11,Lesser Cammie F.12,Lynch Jason P.12,Hava David L.3,Cornish Virginia W.13,Lee Gary K.4,DiAndreth Breanna14,Fero Michael15,Srivastava Rajkamal16,De Coster Tim17,Roybal Kole T.1819,Rackham Owen J. L.20,Kiani Samira21,Zhu Iowis22,Hernandez‐Lopez Rogelio A.23,Guo Tingxi24,Chen William C. W.25

Affiliation:

1. PhD Science Writer New York New York

2. Department of Chemical and Biological Engineering, Center for Synthetic Biology, Interdisciplinary Biological Sciences Program, Chemistry of Life Processes Institute; and Robert H. Lurie Comprehensive Cancer Center Northwestern University Evanston Illinois

3. Research Lab of Electronics Massachusetts Institute of Technology Cambridge Massachusetts

4. Senti Biosciences South San Francisco California

5. MOE Key Laboratory of Bioinformatics and Bioinformatics Division, Center for Synthetic and System Biology, Department of Automation, Beijing National Research Center for Information Science and Technology Tsinghua University Beijing China

6. Synthetic Biology Translational Research Program and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore; NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI) National University of Singapore Singapore

7. Department of Microbial Biotechnology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas (CNB‐CSIC) Madrid Spain

8. Intergalactic Therapeutics Cambridge Massachusetts

9. Division of Surgical Oncology Massachusetts General Hospital Boston Massachusetts

10. Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School Boston and The Broad Institute of MIT and Harvard Cambridge Massachusetts

11. Institute for Research in Biomedicine, and Institute of Oncology Research Università della Svizzera italiana Bellinzona Switzerland

12. Department of Microbiology, Blavatnik Institute, Harvard Medical School and Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine Massachusetts General Hospital Boston Massachusetts

13. Department of Chemistry Columbia University New York New York

14. A2 Biotherapeutics Agoura Hills California

15. TeselaGen Biotechnology San Francisco California

16. Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics Homi Bhabha National Institute (HBNI) Kolkata India

17. Laboratory of Experimental Cardiology, Department of Cardiology Leiden University Medical Center Leiden the Netherlands

18. Department of Microbiology and Immunology and Helen Diller Family Comprehensive Cancer Center University of California, San Francisco San Francisco California

19. Chan Zuckerberg Biohub; Parker Institute for Cancer Immunotherapy Gladstone‐UCSF Institute for Genomic Immunology; and UCSF Cell Design Institute San Francisco California

20. Program in Cardiovascular and Metabolic Disorders Duke‐National University of Singapore Medical School Singapore

21. Division of Experimental Pathology, Department of Pathology School of Medicine; and Pittsburgh Liver Research Center, University of Pittsburgh Pittsburgh Pennsylvania

22. University of California, San Francisco San Francisco California

23. Cell Design Institute, Department of Cellular and Molecular Pharmacology; and Center for Cellular Construction University of California San Francisco San Francisco California

24. Massachusetts Institute of Technology Cambridge Massachusetts

25. Research Laboratory of Electronics and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge; and Cardiovascular Research Center Massachusetts General Hospital Boston Massachusetts

Publisher

Wiley

Subject

History and Philosophy of Science,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Reference90 articles.

1. Developing a new class of engineered live bacterial therapeutics to treat human diseases

2. Beijing Syngentech Co. Ltd.2020.An open‐label phase I/IIa study to evaluate the safety tolerability and efficacy of SynOV1.1 recombinant oncolytic adenovirus injection as monotherapy or in combination with atezolizumab in participants with locally advanced or metastatic hepatocellular carcinoma.clinicaltrials.gov. Accessed Sep. 15 2021.

3. Synlogic.2021.A phase 1 open‐label multicenter study of SYNB1891 administered by intratumoral injection to patients with advanced/metastatic solid tumors and lymphoma alone and in combination with atezolizumab.clinicaltrials.gov. Accessed Sep. 15 2021.

4. Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

5. Synlogic.2021.A double‐blind randomized placebo‐controlled study to assess the safety tolerability and pharmacodynamics of SYNB8802 in healthy volunteers and in patients with enteric hyperoxaluria.clinicaltrials.gov. Accessed Sep. 15 2021.

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