Strategies to overcome the side effects of chimeric antigen receptor T cell therapy

Author:

Mirzaee Godarzee Mohadeseh1,Mahmud Hussen Bashdar2,Razmara Ehsan3ORCID,Hakak‐Zargar Benyamin4ORCID,Mohajerani Fatemeh1,Dabiri Hamed1,Fatih Rasul Mohammed5,Ghazimoradi Mohammad Hossein1,Babashah Sadegh1ORCID,Sadeghizadeh Majid1

Affiliation:

1. Department of Molecular Genetics, Faculty of Biological Sciences Tarbiat Modares University Tehran Iran

2. Department of Pharmacognosy, College of Pharmacy Hawler Medical University Erbil Iraq

3. Australian Regenerative Medicine Institute Monash University, Clayton, Victoria, Australia, 3800

4. Faculty of Health Sciences Simon Fraser University Burnaby British Columbia Canada

5. Department of Medical Analysis, Faculty of Sciences Tishk International University Erbil Iraq

Publisher

Wiley

Subject

History and Philosophy of Science,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Reference188 articles.

1. Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain.

2. In vivo antitumor activity of T cells redirected with chimeric antibody/T cell receptor genes;Hwu P.;Cancer Res,1995

3. CAR T cells for infection, autoimmunity and allotransplantation

4. Recent advances in CAR-T cell engineering

5. Novartis.2017.Novartis receives first ever FDA approval for a CAR‐T cell therapy Kymriah(TM) (CTL019) for children and young adults with B cell ALL that is refractory or has relapsed at least twice.https://www.novartis.com/news/media-releases/novartis-receives-first-ever-fda-approval-car-t-cell-therapy-kymriahtm-ctl019-children-and-young-adults-b-cell-all-refractory-or-has-relapsed-least-twice

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