Affiliation:
1. Graduate School of Science Nagoya University Nagoya Aichi Japan
2. Milk Science Research Institute Megmilk Snow Brand Co., Ltd Kawagoe Saitama Japan
Abstract
AbstractCommensal microbes influence various aspects of vertebrate and invertebrate brain function. We previously reported that Lactiplantibacillus plantarum SBT2227 promotes sleep in the fruit fly, Drosophila melanogaster. However, how widely the sleep‐promoting effects are conserved in gut bacterial species remains unknown. In this study, we orally administered human intestinal and food‐associated bacterial species (39 in total) to flies and investigated their effects on sleep. Six species of bacteria were found to have significant sleep‐promoting effects. Of these, we further investigated Bifidobacterium adolescentis, which had the greatest sleep‐promoting effect, and found that the strength of the sleep effect varied among strains of the same bacterial species. The B. adolescentis strains BA2786 and BA003 showed strong and weak effects on sleep, respectively. Transcriptome characteristics compared between the heads of flies treated with BA2786 or BA003 revealed that the gene expression of the insulin‐like receptor (InR) was increased in BA2786‐fed flies. Furthermore, a heterozygous mutation in InR suppressed the sleep‐promoting effect of BA2786. These results suggest that orally administered sleep‐promoting bacteria (at least BA2786), may act on insulin signaling to modulate brain function for sleep.
Funder
Inamori Foundation
Japan Society for the Promotion of Science
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Editorial: Coevolution of insect-gut microbiome;Frontiers in Ecology and Evolution;2023-08-16