Assessing the efficacy of mesotherapy products: Ultra Exo Booster, and Ultra S Line Plus in hair growth: An ex vivo study

Author:

Zhou Shu Yi12,Giang Nguyen Ngan23,Kim Hyunjee4,Chien Pham Ngoc24,Le Linh Thi Thuy256,Trinh Thuy‐Tien Thi24,Nga Pham Thi24,Kwon Han Jin7,Ham Jung Ryul7,Lee Won Ku7,Gu Yeon Ju7,Zhang Xin Rui12,Jin Yong Xun12,Nam Sun Young2,Heo Chan Yeong1234ORCID

Affiliation:

1. Department of Medicine College of Medicine Seoul National University Seoul South Korea

2. Department of Plastic and Reconstructive Surgery Seoul National University Bundang Hospital Seongnam South Korea

3. Department of Medical Device Development College of Medicine Seoul National University Seoul South Korea

4. Korean Institute of Nonclinical Study H&Bio. Co. Ltd. Seongnam South Korea

5. Department of Biomedical Science College of Medicine Seoul National University Seoul South Korea

6. Faculty of Medical Technique Hai Phong University of Medicine and Pharmacy Haiphong Vietnam

7. UltraV Co., Ltd. R&D Center Seoul South Korea

Abstract

AbstractIn this study, scalp tissues from Korean adults between 20 and 80 without skin disease were used. Scalp tissues were processed, and hair follicles were isolated and cultured with different treatments (including Bioscalp, Ultra Exo Booster, and Ultra S Line Plus) from Ultra V company. Over 12 days, observations and measurements of hair follicle characteristics were recorded at intervals (Days 0, 3, 6, 9, and 12). The study assessed the impact of these substances on hair follicle growth and morphology. Bioscalp, combined with Ultra Exo Booster and Ultra S Line Plus, showed significant hair elongation in ex vivo. Preservation of hair bulb diameter was observed, indicating potential for sustained hair growth by exosome‐based products. The hair growth cycle analysis suggested a lower transition to the catagen stage in test products from Ultra V compared to non‐treated groups. The research findings indicated that the tested formulations, especially the combination of Bioscalp, Ultra Exo Booster, and Ultra S Line Plus, demonstrated significant effectiveness in promoting hair growth, maintaining the integrity of the hair bulb, and reducing the transition to the catagen stage. The study suggests promising alternative treatments for hair loss, illustrating results that were as good as those of the conventional testing product groups.

Funder

Ministry of Trade, Industry and Energy

Publisher

Wiley

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