Romidepsin in peripheral and cutaneous T-cell lymphoma: mechanistic implications from clinical and correlative data

Author:

Bates Susan E.1,Eisch Robin1,Ling Alexander2,Rosing Douglas3,Turner Maria4,Pittaluga Stefania5,Prince H. Miles6,Kirschbaum Mark H.7,Allen Steven L.8,Zain Jasmine9,Geskin Larisa J.10,Joske David11,Popplewell Leslie12,Cowen Edward W.4,Jaffe Elaine S.5,Nichols Jean13,Kennedy Sally14,Steinberg Seth M.15,Liewehr David J.15,Showe Louise C.16,Steakley Caryn17,Wright John18,Fojo Tito17,Litman Thomas19,Piekarz Richard L.18

Affiliation:

1. Developmental Therapeutics Branch; NCI; NIH; Bethesda MD USA

2. Department of Radiology; Warren G Magnuson Clinical Center; NIH; Bethesda MD USA

3. Consultative Cardiology; NHLBI; NIH; Bethesda MD USA

4. Dermatology Branch; NCI; Bethesda MD USA

5. Laboratory of Pathology; CCR; NCI; Bethesda MD USA

6. Peter MacCallum Cancer Centre; East Melbourne Vic. Australia

7. Hematological Malignancies; Penn State Hershey Medical Center; Hershey PA USA

8. Hofstra North Shore-LIJ School of Medicine and Monter Cancer Center; Lake Success NY USA

9. Columbia University; New York NY USA

10. Department of Dermatology; University of Pittsburgh Medical Center; Pittsburgh PA USA

11. Sir Charles Gairdner Hospital; Nedlands; WA Australia

12. City of Hope National Cancer Center; Duarte CA USA

13. Celgene Corporation; Cambridge MA USA

14. Independent Pharmaceutical Consultant; Boston MA USA

15. Biostatistics and Data Management; NCI; Bethesda MD USA

16. The Wistar Institute; Philadelphia PA USA

17. Center for Cancer Research; NCI; Bethesda MD USA

18. Cancer Therapy Evaluation Program; DCTDC; NCI; Bethesda MD USA

19. LEO Pharma A/S; Ballerup Denmark

Funder

National Cancer Institute

Celgene

Publisher

Wiley

Subject

Hematology

Reference67 articles.

1. Laboratory correlates for a phase II trial of romidepsin in cutaneous and peripheral T-cell lymphoma;Bates;British Journal of Haematology,2010

2. PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells;Bhalla;Clinical Cancer Research,2009

3. HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses;Bolden;Cell Death and Disease,2013

4. Systematic assessment of potential cardiac effects of the novel histone deacetylase (HDAC) inhibitor romidepsin;Cabell;Blood (American Society of Hematology Annual Meeting Abstracts),2009

5. Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors;Campbell;Blood,2010

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